Rules of Life Dear Colleague Letter

The Biological Sciences Directorate at NSF has announced a new funding opportunity to support integrative research that crosses the traditional disciplinary boundaries represented by BIO Divisions or between the BIO Directorate and other NSF Directorates. This opportunity represents an initial investment in one of the NSF 10 Big Ideas, called Rules of Life. Rules of Life seeks to highlight the importance of research that forecasts the direction and dynamics of change in living systems. This funding will enable research projects dedicated to understanding processes associated with the emergence of complex properties in biological systems, and identifying underlying general principles (“rules”) across the full spectrum of biological phenomena.

In Rules of Life, “rules” are meant as the general principles or theoretical constructs that explain and predict the characteristics of living systems and for phenomena that cross spatial or organizational levels (from the molecular and sub-cellular to organisms, populations, communities, clades, and biomes) and/or temporal scales (e.g., from macromolecular folding to development to evolutionary processes across all of life. The new Dear Colleague Letter (DCL) outlines which proposal ideas and specific activities are eligible and provides preparation instructions.

The DCL sets out three funding opportunities: Conferences, EAGERs (Early Concept Grants For Exploratory Research), and RAISEs (Research Advanced by Interdisciplinary Science and Engineering). As stated in the DCL, it is important to remember that proposed ideas for Conferences and EAGERs need to appeal to more than one BIO Division; RAISE proposals need to span Directorates. PIs considering an EAGER or RAISE proposal should submit a two-page prospectus outlining their idea by February 20th, 2018. Conference proposals have a submission deadline of June 1st, 2018. PIs should contact a program officer to discuss their idea before submitting a proposal.


Invited proposals should be prepared and submitted according to the guidelines of the NSF Proposal & Award Policies & Procedures Guide (PAPPG). Inquiries should be directed to